The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2010
Filed:
Jan. 27, 2006
Duane C. Eichler, Wesley Chapel, FL (US);
Larry P. Solomonson, Lutz, FL (US);
Laura C. Pendleton, Valrico, FL (US);
Duane C. Eichler, Wesley Chapel, FL (US);
Larry P. Solomonson, Lutz, FL (US);
Laura C. Pendleton, Valrico, FL (US);
University of South Florida, Tampa, FL (US);
Abstract
The present invention is based in part on the discovery that the upstream open reading frame (uORF) in the extended 5'-untranslated region (5′-UTR) argininosuccinate synthase (AS) mRNA species is functional, and when functional, limits overall AS expression as well as nitric oxide (NO) production. Thus, the extended 5′-UTR AS mRNA species is a mechanism for regulating AS expression and NO production, and provides a target for the treatment of pathophysiological conditions associated with vascular endothelial dysfunction and characterized by impairment of NO production, such as heart failure, hypertension, hypercholesterolemia, atherosclerosis, and diabetes.