The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2010
Filed:
Feb. 01, 2005
Ludger Johannes, Courbevoie, FR;
David Grierson, Versaillies, FR;
Sylvie Robine, Vanves, FR;
Jean-claude Florent, Gif-sur-Yvette, FR;
Philipe Maillard, Saint-Cyr-L'Ecole, FR;
Jacky Roger, Villecresnes, FR;
Ludger Johannes, Courbevoie, FR;
David Grierson, Versaillies, FR;
Sylvie Robine, Vanves, FR;
Jean-Claude Florent, Gif-sur-Yvette, FR;
Philipe Maillard, Saint-Cyr-L'Ecole, FR;
Jacky Roger, Villecresnes, FR;
Institut Curie, Cedex, FR;
Centre National de la Recherche Scientifique, Cedex, FR;
Institut National de la Sante et de la Recherche Medicale, Cedex, FR;
Abstract
The invention relates to new compounds for cancer therapy or diagnosis and to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein-STxB is the Shiga Toxin B subunit or a functional equivalent thereof, -Z(n) wherein n is 0 or 1, Z is an amino-acid residue devoid of sulfydryl groups, or is a polypeptide, -T is a molecule linked by a covalent bound to the S part of Cys, selected from: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, - Y(m) wherein m is 0 or 1, Y is a linker between T and Cys, which is either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into cells.