The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2010
Filed:
Oct. 17, 2002
Bernard Maillere, Versailles, FR;
Florence Castelli, Montrouge, FR;
Cécile Buhot, Vitry-sur-Seine, FR;
Bertrand Georges, Bauvin, FR;
Bernard Maillere, Versailles, FR;
Florence Castelli, Montrouge, FR;
Cécile Buhot, Vitry-sur-Seine, FR;
Bertrand Georges, Bauvin, FR;
Commissariat a l'Energie Atomique, Paris, FR;
Sedac Therapeutics, Loos, FR;
Abstract
A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) ZXXXXXXXXXZthereby forming respective complexes, wherein Zand Z, which may be identical or different, are each either zero or from 1 to 100 amino acids; Xis an aromatic or hydrophobic amino acid, or S; Xis an aromatic or hydrophobic amino acid, or C; Xis an aromatic or hydrophobic amino acid, or C, D, Q, S, T, or E; and X, X, X, X, Xand Xare each an amino acid; (ii) separating the respective complexes formed; (iii) detecting the HLA-DP4/labeled peptide complexes; and (iv) selecting the test molecule that exhibits a binding activity of IC<1000 nM, which corresponds to the concentration of the test molecule that inhibits 50% of the competitive HLA-DP4 binding of the labeled peptide.