The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 11, 2010

Filed:

Dec. 11, 2006
Applicants:

Eun Kyung Lee, San Jose, CA (US);

Chris Richard Melville, Palo Alto, CA (US);

David Mark Rotstein, Sunnyvale, CA (US);

Inventors:

Eun Kyung Lee, San Jose, CA (US);

Chris Richard Melville, Palo Alto, CA (US);

David Mark Rotstein, Sunnyvale, CA (US);

Assignee:

Roche Palo Alto LLC, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/40 (2006.01); C07D 487/02 (2006.01); C07D 491/02 (2006.01); C07D 495/02 (2006.01); C07D 497/02 (2006.01); C07D 209/44 (2006.01); C07D 209/52 (2006.01);
U.S. Cl.
CPC ...
Abstract

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.


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