The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 2010
Filed:
Dec. 07, 2006
Biao He, Foster City, CA (US);
Naoaki Fujii, Germantown, TN (US);
Liang You, San Francisco, CA (US);
Zhidong Xu, San Francisco, CA (US);
David M. Jablons, San Francisco, CA (US);
Biao He, Foster City, CA (US);
Naoaki Fujii, Germantown, TN (US);
Liang You, San Francisco, CA (US);
Zhidong Xu, San Francisco, CA (US);
David M. Jablons, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.