The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 11, 2010

Filed:

Apr. 28, 2005
Applicants:

Paolo Carminati, Milan, IT;

Maria Assunta Di Cesare, Rome, IT;

Orlando Ghirardi, Rome, IT;

Patrizia Minetti, Rome, IT;

Maria Ornella Tinti, Rome, IT;

Inventors:

Paolo Carminati, Milan, IT;

Maria Assunta Di Cesare, Rome, IT;

Orlando Ghirardi, Rome, IT;

Patrizia Minetti, Rome, IT;

Maria Ornella Tinti, Rome, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 25/18 (2006.01); A61K 31/407 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH—CHC═CH; R is hydrogen, halogen, C-Calkoxy, C-Calkylthio, C-Calkyl, C-Ccycloalkyl; Ris 1-peperazinyl, 1-homopiperazinyl and 1-piperidinyl; Ris hydrogen, C-Calkoxy, C-Calkylthio, C-Calkyl, CHO, CH═NOH,CHOH. The formula (I) compounds are endowed with characteristic atypical anti-psychotic activity, and are therefore useful as medicaments, in particular for the treatment and prevention of schizophrenia, paranoid states, manic-depressive states, disorders of the affective sphere, social regression, personality regression, and hallucinations. Said compounds also present advantageous pharmacokinetic properties.


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