The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Mar. 17, 2005
Applicants:
Lars Nilsson, Uppsala, SE;
Lars Lannfelt, Uppsala, SE;
Pär Gellerfors, Lidingö, SE;
Inventors:
Assignee:
BioArctic Neuroscience AB, Stockholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); A01K 67/033 (2006.01);
U.S. Cl.
CPC ...
Abstract
A transgenic non-human animal expressing at least one transgene including a DNA sequence encoding a heterologous Amyloid Precursor Protein (APP) including at least the Arctic mutation (E693G) and a further AD (Alzheimer's disease) pathogenic mutation or a further transgene affecting AD pathogenesis, which results in increased amounts of intracellular soluble A aggregates, including A peptides. The method of producing the transgenic animal, and methods of screening for therapeutic or diagnostic agents useful in treatment or diagnosis of Alzheimer's disease are also disclosed.