The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Feb. 17, 2003
Lilian Alcaraz, Loughborough, GB;
Mark Furber, Loughborough, GB;
Mark Purdie, Loughborough, GB;
Brian Springthorpe, Loughborough, GB;
Lilian Alcaraz, Loughborough, GB;
Mark Furber, Loughborough, GB;
Mark Purdie, Loughborough, GB;
Brian Springthorpe, Loughborough, GB;
AstraZeneca AB, , SE;
Abstract
The invention provides compounds of formula (I): wherein: X is CH, O, S(O)or NR; Y is a bond, CH, NR, CHNH, CHNHC(O), CH(OH), CH(NHCOR), CH(NHSOR), CHO or CHS; Z is C(O), or when Y is a bond Z can also be S(O); Ris optionally substituted aryl, optionally substituted heterocyclyl or Ccycloalkyl fused to a benzene ring; and R, R, R, R, R, Rand R, R, R, R, R, Rand Rare as defined herein; are modulators of chemokine (especially CCR3) activity (for use in, for example, treating asthma). The invention also provides a process for making 4-(3,4-dichlorophenoxy)piperidine, which is useful as an intermediate for making certain compounds of the invention.