The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Dec. 08, 2005
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Anil Koul, Berchem, BE;
Jérôme Emile Georges Guillemont, Ande, FR;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Anil Koul, Berchem, BE;
Jérôme Emile Georges Guillemont, Ande, FR;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
Janssen Pharmaceutica N.V., , BE;
Abstract
The present invention relates to a method for the treatment of a bacterial infection comprising administering a therapeutically effective amount of a compound of formula or a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein Ris hydrogen, halo, polyhaloCalkyl, Calkyl, Ar or Het; p is an integer equal to 1 or 2; Ris Calkyloxy, CalkyloxyCalkyloxy or Calkylthio; Ris Ar, Het or Het; Rand Reach independently are hydrogen, Calkyl or benzyl; or Rand Rtogether and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with Calkyl, halo, polyhaloCalkyl, hydroxy, hydroxyCalkyl, Calkyloxy, amino, mono- or di(Calkyl)amino, Calkylthio, CalkyloxyCalkyl, CalkylthioCalkyl or pyrimidinyl; Ris hydrogen, halo, polyhaloCalkyl, Calkyl, Calkyloxy, Calkylthio; or two vicinal Rradicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is an integer equal to 1 or 2; Ris hydrogen, Calkyl, Ar, Het or Het; provided that to bacterial infection is other than a Mycobacterial infection.