Quinazoline derivatives and their use as pharmaceuticals

Abstract

The use of a compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O) or S(O), NH or NRwhere Ris hydrogen or Calkyl; Ris selected from a group NHC(O)OR, NHC(O)R, NHS(O)R, C(O)R, C(O)OR, S(O)R, S(O)OR, S(O)OR, C(O)NRR, S(O)NRRS(O)ONRR, where R, Ror Rare various specified organic groups; Ris hydrogen, optionally substituted hydrocarbyl or optionally substituted heterocyclyl; Rand Rare various specified organic groups, and R, R, R, Rare independently selected from halogeno, cyano, nitro, Calkylsulphanyl, —N(OH)R— (wherein Ris hydrogen, or Calkyl), or RX— (wherein Xrepresents a direct bond, —O—, —CH—, —OCO—, carbonyl, —S—, —SO—, —SO—, —NRCO—, —CONR—, —SONR—, —NRSO— or —NR— (wherein R, Rand Reach independently represents hydrogen, Calkyl or Calkoxy Calkyl), and Ris hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy; in the preparation of a medicament for use in the inhibition of aurora 2 kinase.