The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Mar. 06, 2008
Janine T. Bryan, Furlong, PA (US);
Michelle K. Brownlow, Jamison, PA (US);
LI Shi, Marlborough, MA (US);
Danilo Casimiro, Harleysville, PA (US);
William L. Mcclements, Doylestown, PA (US);
Brian K. Meyer, New Britain, PA (US);
Binghua HU, Audubon, PA (US);
Janine T. Bryan, Furlong, PA (US);
Michelle K. Brownlow, Jamison, PA (US);
Li Shi, Marlborough, MA (US);
Danilo Casimiro, Harleysville, PA (US);
William L. McClements, Doylestown, PA (US);
Brian K. Meyer, New Britain, PA (US);
Binghua Hu, Audubon, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.