The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Mar. 11, 2008
Guo-liang Yu, Berkeley, CA (US);
Jian NI, Germantown, MD (US);
Reiner L. Gentz, Belo Horizonte, BR;
Patrick J. Dillon, Carlsbad, CA (US);
Guo-Liang Yu, Berkeley, CA (US);
Jian Ni, Germantown, MD (US);
Reiner L. Gentz, Belo Horizonte, BR;
Patrick J. Dillon, Carlsbad, CA (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.