The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Feb. 14, 2008
Didier Philippe Robert Schils, Loupoigne, BE;
Joannes Josephus Maria Willems, Oud-Turnhout, BE;
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Jan Heeres, Vosselaar, BE;
Ruben Gerardus George Leenders, Nijmegen, NL;
Jérôme Emile Georges Guillemont, Ande, FR;
Didier Philippe Robert Schils, Loupoigne, BE;
Joannes Josephus Maria Willems, Oud-Turnhout, BE;
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Jan Heeres, Vosselaar, BE;
Ruben Gerardus George Leenders, Nijmegen, NL;
Jérôme Emile Georges Guillemont, Ande, FR;
Janssen Pharmaceutica N.V., , BE;
Abstract
Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: in the presence of a suitable solvent; with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent;