The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Mar. 29, 2005
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Nagabelli Murali, Hyderabad, IN;
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Nagabelli Murali, Hyderabad, IN;
Hetero Drugs Limited, Hyderabad, IN;
Abstract
There is provided an improved process for preparing cefixime. Thus, for example, 7-amino-3-vinyl-3-cephem-4-carboxylic acid is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-(methoxycarbonyl)-methoxyimino acetate in tetrahydrofuran and water at 4° C. in the presence of triethylamine. The reaction mass is extracted with ethyl acetate. 7-[2-(2-Amino-4-thiazolyl)-2-(methoxycarbonylmethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid triethylamine salt present in the aqueous layer is hydrolyzed with sodium hydroxide in less than 30 minutes and aqueous hydrochloric acid is added immediately to adjust the pH to 4.8 to 5.2. Then, aqueous hydrochloric acid is added at 35° C. to adjust the pH 2.5 and cooled to crystallize cefixime trihydrate in high purity.