The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Oct. 05, 2007
Douglas Rehder, Seattle, WA (US);
Pavel Bondarenko, Thousand Oaks, CA (US);
Dirk Chelius, Geretsried, DE;
Arnold Mcauley, Moorpark, CA (US);
Masazumi Matsumura, Thousand Oaks, CA (US);
Douglas Rehder, Seattle, WA (US);
Pavel Bondarenko, Thousand Oaks, CA (US);
Dirk Chelius, Geretsried, DE;
Arnold McAuley, Moorpark, CA (US);
Masazumi Matsumura, Thousand Oaks, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.