The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Sep. 13, 2004
Thomas Rueckle, Plan-les-Ouates, CH;
Pierre-alain Vitte, Cranves-Sales, FR;
Jean-pierre Gotteland, Beaumont, FR;
Thomas Rueckle, Plan-les-Ouates, CH;
Pierre-Alain Vitte, Cranves-Sales, FR;
Jean-Pierre Gotteland, Beaumont, FR;
Merck Serono SA, Coinsins, CH;
Abstract
The present invention is related to the use of sulfonamide derivatives in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS). Formula (I). Ris selected from the group comprising or consisting of hydrogen, C-C-alkoxy, C-C-alkyl, C-C-alkenyl, C-C-alkynyl, amino, sulfanyl, sulfinyl, sulfonyl, sulfonyloxy, sulfonamide, acylamino, aminocarbonyl, C-Calkoxycarbonyl, aryl, heteroaryl, carboxy, cyano, halogen, hydroxy, nitro, hydrazides. Ris selected from the group comprising or consisting of hydrogen, COOR3, —CONRR, OH, a C-Calkyl substituted with an OH or amino group, a hydrazido carbonyl group, a sulfate, a sulfonate, an amine or an ammonium salt. Y is an 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula I thus providing the sulfonamide.