The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Feb. 06, 2001
Marcello Allegretti, I-67100 L'Aquila AQ, IT;
Riccardo Bertini, I-67100 L'Aquila AQ, IT;
Cinzia Bizzarri, I-67100 L'Aquila AQ, IT;
Vilma Sabbatini, I-67100 L'Aquila AQ, IT;
Ginfranco Caselli, I-67100 L'Aquila AQ, IT;
Maria Candida Cesta, I-67100 L'Aquila AQ, IT;
Carmelo Gandolfi, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, Legal Representative, Milan, IT;
Giulio Agostino Gandolfi, Legal Representative, 20156 Milano, IT;
Maria Carla Gandolfi, Legal Representative, Milan, IT;
Arrigo Aldo Gandolfi, Legal Representative, 21097 Saronno, IT;
Francesco Colotta, I-67100 L'Aquila AQ, IT;
Marcello Allegretti, I-67100 L'Aquila AQ, IT;
Riccardo Bertini, I-67100 L'Aquila AQ, IT;
Cinzia Bizzarri, I-67100 L'Aquila AQ, IT;
Vilma Sabbatini, I-67100 L'Aquila AQ, IT;
Ginfranco Caselli, I-67100 L'Aquila AQ, IT;
Maria Candida Cesta, I-67100 L'Aquila AQ, IT;
Carmelo Gandolfi, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, legal representative, Milan, IT;
Giulio Agostino Gandolfi, legal representative, 20156 Milano, IT;
Maria Carla Gandolfi, legal representative, Milan, IT;
Arrigo Aldo Gandolfi, legal representative, 21097 Saronno, IT;
Francesco Colotta, I-67100 L'Aquila AQ, IT;
Other;
Abstract
N-(2-aryl-propionyl)-amides of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of N-(2-aryl-propionyl)amides of formula (I) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.