The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
May. 02, 2003
Chris A. Buhr, Redwood City, CA (US);
Tae-gon Baik, Foster City, CA (US);
Sunghoon MA, Foster City, CA (US);
Zerom Tesfai, Castro Valley, CA (US);
Longcheng Wang, Palo Alto, CA (US);
Erick Wang CO, Redwood City, CA (US);
Sergey Epshteyn, Fremont, CA (US);
Abigail R Kennedy, San Leandro, CA (US);
Baili Chen, Palo Alto, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Neel Kumar Anand, San Mateo, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
John M. Nuss, Danville, CA (US);
Csaba J Peto, Alameda, CA (US);
Kenneth D. Rice, Mill Valley, CA (US);
Mohamed Abdulkader Ibrahim, Mountain View, CA (US);
Kevin Luke Schnepp, Elk Grove, CA (US);
Xian Shi, San Francisco, CA (US);
James William Leahy, San Leandro, CA (US);
Jeff Chen, San Francisco, CA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Timothy Patrick Forsyth, San Mateo, CA (US);
Tai Phat Huynh, Oakland, CA (US);
Grace Mann, Brisbane, CA (US);
Larry Wayne Mann, Redwood City, CA (US);
Craig Stacy Takeuchi, Burlingame, CA (US);
Peter Lamb, Oakland, CA (US);
David J. Matthews, San Francisco, CA (US);
Nicole Miller, San Francisco, CA (US);
Chris A. Buhr, Redwood City, CA (US);
Tae-Gon Baik, Foster City, CA (US);
Sunghoon Ma, Foster City, CA (US);
Zerom Tesfai, Castro Valley, CA (US);
Longcheng Wang, Palo Alto, CA (US);
Erick Wang Co, Redwood City, CA (US);
Sergey Epshteyn, Fremont, CA (US);
Abigail R Kennedy, San Leandro, CA (US);
Baili Chen, Palo Alto, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Neel Kumar Anand, San Mateo, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
John M. Nuss, Danville, CA (US);
Csaba J Peto, Alameda, CA (US);
Kenneth D. Rice, Mill Valley, CA (US);
Mohamed Abdulkader Ibrahim, Mountain View, CA (US);
Kevin Luke Schnepp, Elk Grove, CA (US);
Xian Shi, San Francisco, CA (US);
James William Leahy, San Leandro, CA (US);
Jeff Chen, San Francisco, CA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Timothy Patrick Forsyth, San Mateo, CA (US);
Tai Phat Huynh, Oakland, CA (US);
Grace Mann, Brisbane, CA (US);
Larry Wayne Mann, Redwood City, CA (US);
Craig Stacy Takeuchi, Burlingame, CA (US);
Peter Lamb, Oakland, CA (US);
David J. Matthews, San Francisco, CA (US);
Nicole Miller, San Francisco, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.