The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Jul. 21, 2000
Kevin Jeffrey Barnham, West Brunswick, AU;
Thomas David Mccarthy, Malvern East, AU;
Susanne Pallich, Deer Park, AU;
Barry Ross Matthews, Olinda, AU;
Robert Alan Cherny, Brighton East, AU;
Kevin Jeffrey Barnham, West Brunswick, AU;
Thomas David McCarthy, Malvern East, AU;
Susanne Pallich, Deer Park, AU;
Barry Ross Matthews, Olinda, AU;
Robert Alan Cherny, Brighton East, AU;
Prana Biotechnology Ltd, , AU;
Abstract
The present invention relates to compounds which inhibit the binding of metal ions to a region in the N-terminal loop of the β-amyloid peptide which includes a cluster of histidine residues. In addition, the invention relates to pharmaceutical compositions including these compounds as the active agent, and to methods of treatment involving the administration of these compounds. The compounds of the invention are useful in the treatment of Alzheimer's Disease and other amyloid-related conditions. In a first aspect the present invention provides a compound which interacts with the β-amyloid peptide in such a way that the N-terminal loop of the peptide (amino acid residues 1-15) is blocked or destabilised, thereby inhibiting the binding of one or more metal ions to at least one histidine residue within the N-terminal loop. Preferably the compound inhibits binding of Cu, Znand Feions, but not Mgor Caions.