The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Aug. 16, 2004
Alexander L. Gaeta, Ithaca, NY (US);
Dimitre G. Ouzounov, Ithaca, NY (US);
Watt W. Webb, Ithaca, NY (US);
Rebecca M. Williams, Ithaca, NY (US);
Warren R. Zipfel, Ithaca, NY (US);
Alexander L. Gaeta, Ithaca, NY (US);
Dimitre G. Ouzounov, Ithaca, NY (US);
Watt W. Webb, Ithaca, NY (US);
Rebecca M. Williams, Ithaca, NY (US);
Warren R. Zipfel, Ithaca, NY (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
Abstract
The present invention is directed to a method of applying radiation through an optical fiber for detecting disease within a plant or animal or other penetrable tissue, or imaging a particular tissue of a plant or animal. In addition, fluorescence and nonlinear scattering signals can be detected and localized within a subject by such application of radiation through an optical fiber. The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle to evaluate sub-surface tissue, or with an endoscope to evaluate tissue within body cavities. The present invention also relates to a device for coupling in radiation from an ultrashort mode-locked laser into the beam path of a microscope.