The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2010

Filed:

Jun. 04, 2002
Applicants:

Masahiro Hiraoka, Sakyo-ku, Kyoto-shi, Kyoto 606-0033, JP;

Shinae Kondoh, Kitagosho-machi, Sakyo-ku, Kyoto-shi, Kyoto 606-8336, JP;

Hiroshi Harada, Yokohama, JP;

Inventors:

Masahiro Hiraoka, Sakyo-ku, Kyoto-shi, Kyoto 606-0033, JP;

Shinae Kondoh, Kitagosho-machi, Sakyo-ku, Kyoto-shi, Kyoto 606-8336, JP;

Hiroshi Harada, Yokohama, JP;

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 21/02 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

To identify a domain in HIF-1α protein, which participates in stabilization of a fused protein, DNA encoding the following polypeptide (A) or (B) is provided: (A) a polypeptide having the amino acid sequence of SEQ ID NO: 1 (B) a polypeptide having an amino acid sequence comprising at least 16 amino acid residues in the amino acid sequence of SEQ ID NO: 1, and imparting stability dependent on an oxygen concentration to other protein in a cell harboring a fused protein, when the polypeptide is fused with a nuclear localization signal and the other protein to form the fused protein.


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