The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Apr. 08, 2009
Brian M. Beyer, Aberdeen, NJ (US);
Richard N. Ingram, Scotch Plains, NJ (US);
Peter Orth, New York, NY (US);
Corey O. Strickland, Martinsville, NJ (US);
Brian M. Beyer, Aberdeen, NJ (US);
Richard N. Ingram, Scotch Plains, NJ (US);
Peter Orth, New York, NY (US);
Corey O. Strickland, Martinsville, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In addition, the present invention discloses methods of using the proteins, crystals and/or three-dimensional structures obtained to identify compounds that can modulate the enzymatic activity of TACE.