The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Jun. 29, 2006
Susan E. Lacy, Shrewsbury, MA (US);
Emma Fung, Shrewsbury, MA (US);
Jonathan P. Belk, Sterling, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Michael Roguska, Ashland, MA (US);
Paul R. Hinton, Sunnyvale, CA (US);
Shankar Kumar, Pleasanton, CA (US);
Susan E. Lacy, Shrewsbury, MA (US);
Emma Fung, Shrewsbury, MA (US);
Jonathan P. Belk, Sterling, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Michael Roguska, Ashland, MA (US);
Paul R. Hinton, Sunnyvale, CA (US);
Shankar Kumar, Pleasanton, CA (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.