The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Nov. 06, 2007
Applicants:
Shu-wha Lin, Taipei, TW;
Chia-ni Lin, Taipei, TW;
Hua-lin Wu, Tainan, TW;
Guey-yueh Shi, Tainan, TW;
Inventors:
Shu-Wha Lin, Taipei, TW;
Chia-Ni Lin, Taipei, TW;
Hua-Lin Wu, Tainan, TW;
Guey-Yueh Shi, Tainan, TW;
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/14 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention aims at converting factor IX into a molecule with enhanced activity which provides an alternative for replacement therapy and gene therapy for hemophilia B. Using recombinant techniques, factor IX having substitution of amino acid residue of SEQ ID NO: 7 at amino acid position selected from the group consisting of 86, 277, and 338 (exclude the circumstance of a single substitution at amino acid position 338) exhibits better clotting activity than recombinant wild type factor IX.