The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Aug. 31, 2005
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Hohen Neuendorf, DE;
Jens Hoffmann, Muehlenbeck, DE;
Rosemarie Lichtner, Berlin, DE;
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Hohen Neuendorf, DE;
Jens Hoffmann, Muehlenbeck, DE;
Rosemarie Lichtner, Berlin, DE;
Bayer Schering Pharma Aktiengesellschaft, Berlin, DE;
Abstract
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R, R, R, R, R, R, R, R, R, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.