The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2010

Filed:

Jun. 07, 2006
Applicants:

Anthony A. Gatenby, Wilmington, DE (US);

Ranjan Patnaik, Newark, DE (US);

Fateme Sima Sariaslani, Wilmington, DE (US);

Wonchul Suh, Hockessin, DE (US);

Tina K. Van Dyk, Wilmington, DE (US);

Inventors:

Anthony A. Gatenby, Wilmington, DE (US);

Ranjan Patnaik, Newark, DE (US);

Fateme Sima Sariaslani, Wilmington, DE (US);

Wonchul Suh, Hockessin, DE (US);

Tina K. Van Dyk, Wilmington, DE (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 13/22 (2006.01); C12P 21/06 (2006.01); C12P 19/34 (2006.01); C12N 15/87 (2006.01); C12N 15/74 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.


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