The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Dec. 16, 2002
Kathryn T. Hall, Boston, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Joachim L. Schultze, Cologne, DE;
Vassiliki A. Boussiotis, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Laurence Boumsell, Creteil, FR;
Armand Bensussan, Creteil, FR;
Kathryn T. Hall, Boston, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Joachim L. Schultze, Cologne, DE;
Vassiliki A. Boussiotis, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Laurence Boumsell, Creteil, FR;
Armand Bensussan, Creteil, FR;
Dana-Farber Cancer Institute, Boston, MA (US);
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris Cedex, FR;
Abstract
Isolated nucleic acid molecules encoding novel CD100 molecules which stimulate a leukocyte response, such as a B cell response, including B cell aggregation, B cell differentiation, B cell survival, and/or T cell proliferation are disclosed. These novel molecules have a certain homology to semaphorins, proteins which are growth cone guidance molecules that are critical for guiding growing axons of neurons to their targets. In addition to isolated nucleic acids molecules, antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced are also described. The invention further provides isolated CD100 proteins, fusion proteins and active fragments thereof. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.