The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Jan. 22, 2007
Kristina M. Allen, Hopkinton, MA (US);
Anthony Anisowicz, West Newton, MA (US);
Veronique Damagnez, Framingham, MA (US);
John A. Robinson, Downington, PA (US);
Paul J. Yaworsky, Rockland, MA (US);
Bheem M. Bhat, West Chester, PA (US);
Kristina M. Allen, Hopkinton, MA (US);
Anthony Anisowicz, West Newton, MA (US);
Veronique Damagnez, Framingham, MA (US);
John A. Robinson, Downington, PA (US);
Paul J. Yaworsky, Rockland, MA (US);
Bheem M. Bhat, West Chester, PA (US);
Wyeth, Madison, NJ (US);
Oscient Pharmaceuticals Corporation, Waltham, MA (US);
Abstract
The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.