The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Mar. 07, 2007
Roy Clifford Levitt, Ambler, PA (US);
W. Lee Maloy, Lansdale, PA (US);
U. Prasad Kari, Hatfield, PA (US);
Nicholas C. Nicolaides, Media, PA (US);
Roy Clifford Levitt, Ambler, PA (US);
W. Lee Maloy, Lansdale, PA (US);
U. Prasad Kari, Hatfield, PA (US);
Nicholas C. Nicolaides, Media, PA (US);
Genaera Corporation, Plymouth Meeting, PA (US);
Abstract
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual.