The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2010
Filed:
Feb. 21, 2005
Masahiro Okuyama, Osaka, JP;
David Selwood, London, GB;
Cristina Visintin, London, GB;
David Baker, London, GB;
Gareth Pryce, London, GB;
Masahiro Okuyama, Osaka, JP;
David Selwood, London, GB;
Cristina Visintin, London, GB;
David Baker, London, GB;
Gareth Pryce, London, GB;
University College London, London, GB;
Abstract
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is ORor NRRwherein each of Rand Ris independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO-alkyl, alkenyl, CN, NH, hydroxy, halo, alkoxy, CFand nitro; Y is a polar functional group selected from OH, NO, CN, COR, COOR, NRR, CONRR, SOH, SO—R, SONRRand CF, where each of Rand Ris independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X—Y is other than meta-C≡—C—(CH)COH, meta-C≡—C—(CH)OH, meta-C≡C—(CH)COMe, meta-(CH)COH, ortho-CHCOH, ortho-(CH)COH and ortho-(CH)COH; and (ii) when A is phenyl, n is 0, and Z is OMe, X—Y is other than meta-C≡C—(CH)OH. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.