The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 13, 2010

Filed:

Apr. 16, 2004
Applicants:

Ashok Tehim, Ridgewood, NJ (US);

Allen Hopper, Glen Rock, NJ (US);

Ruiping Liu, Huntington, NY (US);

Erik Kuester, Franklin, NJ (US);

Robert F. Dunn, Towaco, NJ (US);

Thomas E. Renau, San Carlos, CA (US);

Inventors:

Ashok Tehim, Ridgewood, NJ (US);

Allen Hopper, Glen Rock, NJ (US);

Ruiping Liu, Huntington, NY (US);

Erik Kuester, Franklin, NJ (US);

Robert F. Dunn, Towaco, NJ (US);

Thomas E. Renau, San Carlos, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/54 (2006.01); A61K 31/425 (2006.01); C07D 417/02 (2006.01); C07D 413/02 (2006.01); C07D 405/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein.


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