The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2010
Filed:
Oct. 08, 2003
Hans-peter Hohmann, Upper Montclair, NJ (US);
Nigel John Mouncey, Verona, NJ (US);
Heinrich Winfred Schlieker, Bloomfield, NJ (US);
Jeffrey W. Stebbins, Nutley, NJ (US);
Hans-Peter Hohmann, Upper Montclair, NJ (US);
Nigel John Mouncey, Verona, NJ (US);
Heinrich Winfred Schlieker, Bloomfield, NJ (US);
Jeffrey W. Stebbins, Nutley, NJ (US);
DSM IP Assets B.V., Te Heerlen, NL;
Abstract
The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided. The polynucleotide sequences of the present invention include sequences derived from the biotin operon ofand in particular the bioFDB gene cassette.