The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2010
Filed:
Jun. 30, 2004
Thomas W. Dubensky, Jr., Piedmont, CA (US);
Dirk G. Brockstedt, Richmond, CA (US);
John E. Hearst, Berkeley, CA (US);
David N. Cook, Lafayette, CA (US);
William S. Luckett, Jr., Richmond, CA (US);
Thomas W. Dubensky, Jr., Piedmont, CA (US);
Dirk G. Brockstedt, Richmond, CA (US);
John E. Hearst, Berkeley, CA (US);
David N. Cook, Lafayette, CA (US);
William S. Luckett, Jr., Richmond, CA (US);
Aduro Biotech, Berkeley, CA (US);
Abstract
Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.