The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Feb. 28, 2006
Brian M. Aquila, Marlborough, MA (US);
Thomas D. Bannister, Northborough, MA (US);
Gregory D. Cuny, Somerville, MA (US);
James R. Hauske, Concord, MA (US);
Michele L. R. Heffernan, Worcester, MA (US);
Michael Z. Hoemann, Marlborough, MA (US);
Donald W. Kessler, Groton, MA (US);
Liming Shao, Lincoln, MA (US);
Xinhe Wu, Shrewsbury, MA (US);
Roger L. Xie, Natick, MA (US);
Brian M. Aquila, Marlborough, MA (US);
Thomas D. Bannister, Northborough, MA (US);
Gregory D. Cuny, Somerville, MA (US);
James R. Hauske, Concord, MA (US);
Michele L. R. Heffernan, Worcester, MA (US);
Michael Z. Hoemann, Marlborough, MA (US);
Donald W. Kessler, Groton, MA (US);
Liming Shao, Lincoln, MA (US);
Xinhe Wu, Shrewsbury, MA (US);
Roger L. Xie, Natick, MA (US);
Sepracor Inc., Marlborough, MA (US);
Abstract
One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.