The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Aug. 24, 2004
Hideki Narumi, Kamakura, JP;
Yoshiaki Tsushima, Kamakura, JP;
Koji Yamashita, Fujisawa, JP;
Saburou Sone, Yokohama, JP;
Miyuki Sato, Kamakura, JP;
Hideki Narumi, Kamakura, JP;
Yoshiaki Tsushima, Kamakura, JP;
Koji Yamashita, Fujisawa, JP;
Saburou Sone, Yokohama, JP;
Miyuki Sato, Kamakura, JP;
Toray Industries, Inc., , JP;
Other;
Abstract
The present invention relates to a complex between interferon-β and polyethylene glycol, which has high biological activity, and to a method for producing the complex at high efficiency. Namely, the present invention relates to a method for producing an interferon-β complex comprising binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, their corresponding sugar alcohols, and Cpolyhydric alcohols, and to an interferon-β complex produced by the method, which has polyethylene glycol specifically bound with lysine located at the 19th or 134th position in the amino acid sequence of interferon-β.