The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Jun. 04, 2007
Pier Giovanni Baraldi, Ferrara, IT;
Pier Andrea Borea, Ferrara, IT;
Allan R. Moorman, Durham, NC (US);
Delia Preti, Ferrara, IT;
Pier Giovanni Baraldi, Ferrara, IT;
Pier Andrea Borea, Ferrara, IT;
Allan R. Moorman, Durham, NC (US);
Delia Preti, Ferrara, IT;
King Pharmaceuticals Research and Development, Inc., Cary, NC (US);
Abstract
The present invention provides compounds of the formula wherein R, R, Rand n have meaning as described in the specification, methods for their preparation, and pharmaceutical compositions containing them. The compounds of formula (I) are adenosine Areceptor agonists and, thus, may be employed for the treatment of diseases in mammals that are mediated by the Areceptor including, but not limited to, septic shock, cystic fibrosis, impotence, diarrhea, and cardiac diseases. Cardiac diseases include hyperplasia consequent to hypertension, arteriosclerosis, and heart attack. The present invention also provides methods for the induction of pharmacological stress to facilitate coronary imaging of areas of ischemia by employing compounds of formula (I). The compounds of formula (I) may be labeled, e.g., with radioactive isotopes, and therefore are useful in kinetic binding experiments.