The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Sep. 19, 2003
Carl Gustav Figdor, Den Bosch, NL;
Ruurd Torensma, Nijmegen, NL;
Petrus Leonardus Everardus Maria Van Lent, Nijmegen, NL;
Wim B. Van Den Berg, Molenhoek, NL;
Carl Gustav Figdor, Den Bosch, NL;
Ruurd Torensma, Nijmegen, NL;
Petrus Leonardus Everardus Maria Van Lent, Nijmegen, NL;
Wim B. Van Den Berg, Molenhoek, NL;
Stichting Katholieke Universiteit, Nijmegen, NL;
Abstract
The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.