The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Jan. 31, 2006
Harold G. Craighead, Ithaca, NY (US);
Bojan Ilic, Ithaca, NY (US);
David Alan Czaplewski, Ithaca, NY (US);
Robert H. Hall, Clarksville, MD (US);
Harold G. Craighead, Ithaca, NY (US);
Bojan Ilic, Ithaca, NY (US);
David Alan Czaplewski, Ithaca, NY (US);
Robert H. Hall, Clarksville, MD (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
Abstract
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first resonant frequency is determined for the cantilever having the immobilized binding partner. Upon exposure of the cantilever to a solution that binds with the binding partner, the mass of the cantilever beam increases. A second resonant frequency is determined and the differential resonant frequency provides the basis for detecting the target cell or molecule. The cantilever may be driven externally or by ambient noise. The frequency response of the beam can be determined optically using reflected light and two photodetectors or by interference using a single photodetector.