The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Oct. 10, 2002
Eulalia Ferret, El Prat De Llobregat, ES;
Miguel Angel Asin, Cerdanyola Del Valles, ES;
Jesus Garcia, Barcelona, ES;
Pere Tarin, Sabadell, ES;
Rosa Arola, Barcelona, ES;
Montserrat Rutllan, Barcelona, ES;
Amadeo Perez, Barcelona, ES;
Eulalia Ferret, El Prat De Llobregat, ES;
Miguel Angel Asin, Cerdanyola Del Valles, ES;
Jesus Garcia, Barcelona, ES;
Pere Tarin, Sabadell, ES;
Rosa Arola, Barcelona, ES;
Montserrat Rutllan, Barcelona, ES;
Amadeo Perez, Barcelona, ES;
Pierre Fabre Medicament, Boulogne-Billancourt, FR;
Abstract
The invention concerns a method for preparing a pharmaceutical composition in the form of microspheres with prolonged release of a water-soluble active principle. The invention is characterized in that it comprises the following successive steps: dissolving an active principle in an appropriate amount of water; emulsifying the resulting aqueous solution of active principle with a d,l-lactide-co-glycolide matrix copolymer, of average molecular weight ranging between 40000 and 80000, dissolved in a chlorinated hydrocarbon, resulting in a first microfine and homogeneous emulsion; emulsifying said resulting first emulsion in an external aqueous phase, containing a surfactant, a viscosity-enhancing agent and an osmotic agent; extraction-evaporation of the solvent to obtain microspheres which are recuperated after filtering, washing and drying. The invention also concerns microspheres obtainable by implementing said method, having continuous release over a period of more than two months, advantageously over a period of at least three months.