The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2010
Filed:
Jun. 15, 2005
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Dandamudi Satish Kumar, Hyderabad, IN;
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Dandamudi Satish Kumar, Hyderabad, IN;
Hetero Drugs Limited, Hyderabad, IN;
Abstract
The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropyl)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.