The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2010
Filed:
Oct. 14, 2003
Applicants:
Klaus Peter Stengele, Pleiskirchen, DE;
Evgueni Kvassiouk, Waldkraiburg, DE;
Inventors:
Klaus Peter Stengele, Pleiskirchen, DE;
Evgueni Kvassiouk, Waldkraiburg, DE;
Assignee:
NIMBLEGEN SYSTEMS GmbH, Pleiskirchen, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C12Q 1/68 (2006.01); C07H 21/02 (2006.01); C07H 19/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a method for the manufacture of labeled oligonucleotide conjugates comprising the reaction of (a) an oligonucleotide having a labile protecting group bound to a terminal hydroxy group, and (b) a labeling compound, wherein said labile protecting group is partially or completely substituted by said labeling compound in a nucleophilic substitution reaction.