The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2010
Filed:
Aug. 16, 2006
Chad E. Bennett, Metuchen, NJ (US);
William J. Greenlee, Teaneck, NJ (US);
Chad E. Knutson, Garwood, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Chad E. Bennett, Metuchen, NJ (US);
William J. Greenlee, Teaneck, NJ (US);
Chad E. Knutson, Garwood, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J-J, X, Z, and R, R, and Rare as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.