The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2010
Filed:
Oct. 16, 2007
Kesavaram Narkunan, San Antonio, TX (US);
Xinghai Chen, San Antonio, TX (US);
Harry Kochat, San Antonio, TX (US);
Frederick Hausheer, Boerne, TX (US);
Kesavaram Narkunan, San Antonio, TX (US);
Xinghai Chen, San Antonio, TX (US);
Harry Kochat, San Antonio, TX (US);
Frederick Hausheer, Boerne, TX (US);
BioNumerik Pharmaceuticals, Inc., San Antonio, TX (US);
Abstract
The novel C10-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells in vitro; (ii) are potent inhibition of Topoisomerase I; (iii) lack of susceptibility to MDR/MRP drug resistance; (iv) require no metabolic drug activation: (v) lack glucuronidation of the A-ring or B-ring; (vi) reduce drug-binding affinity to plasma proteins; (vii) maintain lactone stability; (viii) maintain drug potency; and (ix) possess a low molecular weight (e.g., MW<600).