The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2010
Filed:
Jun. 10, 2004
Viviana Braude, Kadima, IL;
Nina Finkelstein, Herzliya, IL;
Kobi Chen, Ramat HaSharon, IL;
Gideon Pilarsky, Holon, IL;
Anita Liberman, Tel-Aviv, IL;
Claude Singer, Kfar Saba, IL;
Yuriy Raizi, Natanya, IL;
Viviana Braude, Kadima, IL;
Nina Finkelstein, Herzliya, IL;
Kobi Chen, Ramat HaSharon, IL;
Gideon Pilarsky, Holon, IL;
Anita Liberman, Tel-Aviv, IL;
Claude Singer, Kfar Saba, IL;
Yuriy Raizi, Natanya, IL;
Teva Pharmaceutical Industries Ltd, Petah Tiqva, IL;
Abstract
The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chlorohydroxymethyl]sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.