The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 23, 2010

Filed:

Apr. 14, 2006
Applicants:

Shyi-tai Jan, Cary, NC (US);

Kwen-jen Chang, Chapel Hill, NC (US);

Kestutis P. Biciunas, Durham, NC (US);

Xin MA, Carrboro, NC (US);

Inventors:

Shyi-Tai Jan, Cary, NC (US);

Kwen-Jen Chang, Chapel Hill, NC (US);

Kestutis P. Biciunas, Durham, NC (US);

Xin Ma, Carrboro, NC (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 245/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.


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