The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2010
Filed:
Mar. 07, 2003
Siegfried Ansorge, Hohenwarthe, DE;
Harald Gollnick, Magdeburg, DE;
Klaus Neubert, Halle, DE;
Christos Zouboulis, Berlin, DE;
Jurgen Faust, Halle, DE;
Uwe Lendeckel, Magdeburg, DE;
Dirk Reinhold, Magdeburg, DE;
Robert Vetter, Magdeburg, DE;
Siegfried Ansorge, Hohenwarthe, DE;
Harald Gollnick, Magdeburg, DE;
Klaus Neubert, Halle, DE;
Christos Zouboulis, Berlin, DE;
Jurgen Faust, Halle, DE;
Uwe Lendeckel, Magdeburg, DE;
Dirk Reinhold, Magdeburg, DE;
Robert Vetter, Magdeburg, DE;
IMTM GmbH, Magdeburg, DE;
Abstract
The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.