The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 16, 2010

Filed:

Oct. 16, 2007
Applicants:

Donatella Chianelli, San Diego, CA (US);

Christopher Cow, San Diego, CA (US);

Yun He, Shanghai, CN;

Songchun Jiang, San Diego, CA (US);

Xiaolin LI, San Diego, CA (US);

Xiaodong Liu, San Diego, CA (US);

Zuosheng Liu, San Diego, CA (US);

Jon Loren, San Diego, CA (US);

Valentina Molteni, San Diego, CA (US);

Juliet Nabakka, Santee, CA (US);

Pingda Ren, San Diego, CA (US);

Taebo Sim, Seoul, KR;

Xiaodong Wang, Chapel Hill, NC (US);

Shuli You, Shanghai, CN;

Inventors:

Donatella Chianelli, San Diego, CA (US);

Christopher Cow, San Diego, CA (US);

Yun He, Shanghai, CN;

Songchun Jiang, San Diego, CA (US);

Xiaolin Li, San Diego, CA (US);

Xiaodong Liu, San Diego, CA (US);

Zuosheng Liu, San Diego, CA (US);

Jon Loren, San Diego, CA (US);

Valentina Molteni, San Diego, CA (US);

Juliet Nabakka, Santee, CA (US);

Pingda Ren, San Diego, CA (US);

Taebo Sim, Seoul, KR;

Xiaodong Wang, Chapel Hill, NC (US);

Shuli You, Shanghai, CN;

Assignee:

IRM LLC, Hamilton, BM;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/4375 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/5355 (2006.01); A61K 31/506 (2006.01); C07D 413/14 (2006.01); C07D 213/69 (2006.01); C07D 213/61 (2006.01); C07D 213/74 (2006.01); C07D 213/80 (2006.01); C07C 205/06 (2006.01); C07C 301/00 (2006.01); C07C 255/07 (2006.01); C07C 69/73 (2006.01); A61P 17/10 (2006.01); A61P 29/00 (2006.01); A61P 3/10 (2006.01); A61P 31/00 (2006.01); A61P 27/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.


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