The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 16, 2010

Filed:

Jul. 12, 2007
Applicants:

Charles Z. Ding, Plano, TX (US);

IN Ho Kim, Dublin, OH (US);

Jiancheng Wang, Addison, TX (US);

Zhenkun MA, Westfield, NJ (US);

Yafei Jin, Ann Arbor, MI (US);

Keith D. Combrink, Arlington, TX (US);

Genliang LU, Plano, TX (US);

A. Simon Lynch, Dallas, TX (US);

Inventors:

Charles Z. Ding, Plano, TX (US);

In Ho Kim, Dublin, OH (US);

Jiancheng Wang, Addison, TX (US);

Zhenkun Ma, Westfield, NJ (US);

Yafei Jin, Ann Arbor, MI (US);

Keith D. Combrink, Arlington, TX (US);

Genliang Lu, Plano, TX (US);

A. Simon Lynch, Dallas, TX (US);

Assignee:

Cumbre IP Ventures, L.P., Dallas, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/22 (2006.01); A61K 31/535 (2006.01); A61P 31/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Substituted rifamycin derivatives in which a nitroimidazole, nitrothiazole or nitrofuran pharmacophore is covalently bonded to a rifamycin, methods of using the rifamycin derivatives, and pharmaceutical compositions containing the rifamycin derivatives are disclosed. Methods of synthesizing these substituted rifamycin derivatives are also disclosed. The rifamycin derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.


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