The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2010
Filed:
Feb. 09, 2006
Roelof W. Feenstra, Weesp, NL;
Hiskias G. Keizer, Weesp, NL;
Maria L. Pras-raves, Weesp, NL;
Bernard J Van Vliet, Weesp, NL;
Gustaaf J. M. Van Scharrenburg, Weep, NL;
Roelof W. Feenstra, Weesp, NL;
Hiskias G. Keizer, Weesp, NL;
Maria L. Pras-Raves, Weesp, NL;
Bernard J Van Vliet, Weesp, NL;
Gustaaf J. M. Van Scharrenburg, Weep, NL;
Solvay Pharmaceuticals B.V., Weesp, NL;
Abstract
The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): whereinwherein the symbols have the meanings given in the specification.