The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2010
Filed:
Aug. 28, 2008
Zhan-qi Niu, Hebei, CN;
Kai Zhao, Hebei, CN;
Wen-juan Liu, Hebei, CN;
Gui-rong Zhou, Hebei, CN;
Chao Liu, Hebei, CN;
Rong-duan Wang, Hebei, CN;
Hong-zhong Yuan, Hebei, CN;
Wen-min Guo, Hebei, CN;
Sui-chao Yan, Hebei, CN;
Min Bai, Hebei, CN;
Zhan-qi Niu, Hebei, CN;
Kai Zhao, Hebei, CN;
Wen-juan Liu, Hebei, CN;
Gui-rong Zhou, Hebei, CN;
Chao Liu, Hebei, CN;
Rong-duan Wang, Hebei, CN;
Hong-zhong Yuan, Hebei, CN;
Wen-min Guo, Hebei, CN;
Sui-chao Yan, Hebei, CN;
Min Bai, Hebei, CN;
Abstract
The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-β-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.